In vertebrates. the conserved Wnt signalling cascade promotes the stabilization and nuclear accumulation of beta-catenin. which then associates with the lymphoid enhancer factor/T cell factor proteins (LEF/TCFs) to activate target genes. Wnt/beta -catenin signalling is essential for T cell development and differentiation. https://chefesquipmenters.shop/product-category/covers-round-inserts/