Background & Aims: HBV persists in the nucleus of infected hepatocytes as a covalently closed circular DNA (cccDNA) episome that constitutes the template for viral RNA and protein synthesis. Both HBx and HBc (core) viral proteins associate with cccDNA but. while HBx is required for viral transcription. the role of HBc is still unclear. https://www.jmannino.com/quick-offer-Nemacor-Maxx-4-for-Dogs-flash-choice/